Expression of EpCAM and EpCAM variants in human carcinomas
نویسندگان
چکیده
Tyrolean Cancer Research Institute, Innsbruck, Austria Oncotyrol—Center for Personalized Cancer Medicine, Innsbruck, Austria Department of Haematology and Oncology, Medical University of Innsbruck, Innsbruck, Austria Haemato-Oncological Day Hospital, Tappeiner Hospital, Merano, Italy Molecular Pathology Division, Institute of Pathology, University of Basel, Basel, Switzerland Department of Pathology, Regional Hospital of Bolzano, Bolzano, Italy
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Expression of EpCAMMF and EpCAMMT variants in human carcinomas
AIMS Regulated intramembrane proteolysis has been shown to be an important mechanism for oncogenic activation of epithelial cell adhesion molecule (EpCAM) through nuclear translocation of the intracellular domain EpICD. Recent studies have identified new membrane-bound EpCAM variants. To evaluate the prevalence of two membranous EpCAM variants in human tumours, we performed a large-scale expres...
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Epithelial cell adhesion molecule EpCAM is strongly over-expressed in a variety of carcinomas where it is involved in signalling events resulting in increased expression of target genes such as c-Myc, cyclins and others, eventually conferring cells an oncogenic phenotype. However, EpCAM is also expressed in a series of healthy epithelia, albeit generally to a far lesser extend. We have uncovere...
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AIMS Epithelial cell adhesion molecule (EpCAM) is a cell surface protein with oncogenic features that is expressed on healthy human epithelia and corresponding malignant tumours. EpCAM expression frequently correlates with more aggressive tumour behaviour and new EpCAM-specific therapeutic agents have recently been approved for clinical use in patients with cancer. However, no consensus exists ...
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BACKGROUND Recent studies have revealed that a small subset of Lynch syndrome-associated colorectal carcinomas (CRCs) is caused by a germline EPCAM deletion-induced MSH2 epimutation. Based on the finding of this genetic alteration, we investigated the implications of EPCAM expression changes in microsatellite instability-high (MSI-H) CRCs. METHODS Expression of EPCAM and DNA mismatch repair p...
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The epithelial cell adhesion molecule (EpCAM) gene has been found to be highly expressed in carcinomas of various origins; however, the molecular mechanisms underlying the transcriptional regulation of EpCAM remain poorly understood. The purpose of this experiment was to study the relationship between EpCAM gene overexpression and CpG island methylation status in the promoter region in cell cul...
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